Nearly one in six men is affected by infertility related to problems with their sperm. The causes can range from hereditary factors and lifestyle choices to past infections and a person’s age.
Sperm Abnormalities
The term oligoasthenoteratozoospermia, or OAT, is used when all three of the following factors are present:
An abnormally low level of sperm of a healthy shape (teratozoospermia)An abnormally low amount of sperm (oligozoospermia)An abnormally low amount of sperm with good motility (asthenozoospermia)
Idiopathic oligoasthenoteratozoospermia is used when the cause of the condition is unclear. Up to 30% of male infertility cases are said to have idiopathic OAT. The factors for OAT can be broadly broken down into five categories: genetic factors, lifestyle factors, environmental factors, medical factors, and testicular factors. The treatment options available will depend on the cause of OAT.
Genetic Causes
Genetic factors can affect every stage of male fertility—from DNA damage in sperm cells (spermatozoa), genetic defects of the Y chromosome, and genetic disorders like Klinefelter syndrome, in which men have an extra X chromosome. While most genetic factors are not treatable, they can often be overcome with the use of in vitro fertilization (IVF).
Lifestyle Causes
Lifestyle factors involve both habits and conditions that directly affect the sperm. Many of these factors can be changed, and doing so can significantly improve a person’s chance of conceiving.
Alcohol and Drug Use
As few as five drinks per week can significantly lower testosterone levels and sperm quality. Many recreational drugs have the same effect. Using anabolic steroids is also known to cause OAT.
Heat
Overheating the testes is associated with a low sperm count. Causes include taking very hot showers, baths, or saunas, as well as wearing tight briefs instead of boxers. A sedentary lifestyle and certain professions like being a cab driver or frequently sitting with a laptop directly on your lap can also lead to the overheating of the testicles. Overexertion at the gym can also have the same effect. Typically, once the activity causing excess heat is stopped, sperm production returns to normal.
Smoking
Smoking is strongly linked to male infertility although the reasons are not entirely clear. Smoking can reduce sperm count by 17.5% and sperm motility by 16.6%.
Strenuous Activities
Strenuous exercise like riding (cycling, horseback) can cause testicular inflammation. This can be relieved by simply taking a break from the activity.
Weight
Obesity and being overweight are known to cause hormonal changes that can directly impact fertility. Being underweight can also have a negative effect.
Environmental Factors
Exposure to environmental toxins can also cause low sperm count. Environmental factors that may adversely impact sperm counts include exposure to heavy metals and industrial chemicals. Some of the chemicals and metals that can decrease sperm counts are benzenes, dioxins, lead, herbicides, pesticides, painting materials, and organic solvents.
Medical Factors
There are a variety of medical issues that can cause OAT. These include injury, current or past infections, medications, and other medical conditions,
Medical Conditions
Some medical conditions like cystic fibrosis, celiac disease, tumors, hormonal imbalances, and cancer can impact sperm production. Problems with the immune system can cause antibodies that attack sperm. Other chronic health issues, such as diabetes, may cause erectile dysfunction. Sexually transmitted infections (STIs) can also impact male fertility.
Testicular Problems
Testicular factors can interfere with the testicle’s ability to produce ample quantity or quality of sperm. Some of these issues can be treated but others cannot. Examples of factors that can impact testicular function include:
Certain past infections (syphilis, mumps, malaria) that are known to either directly or indirectly affect the male reproductive systemChemotherapy and radiation therapyOlder agePast surgery or other medical procedures to the reproductive systemTesticular cancerTesticular traumaVaricocele, also called varicose veins of the scrotum, an enlargement and swelling of veins in the scrotum that can often be treated surgically and non-surgically
Testicular and Ejaculatory Dysfunction
Testicular and ejaculatory dysfunction refers to any condition that impedes the ability to ejaculate or obstructs the flow of semen in the male genital tract. These include:
Erectile dysfunctionHypospadias, a congenital defect in which the opening of the urethra is not situated on the head of the penisObstruction of the vas deferens or ejaculatory ductProstatitis (inflammation of the prostate gland)Retrograde ejaculation, where semen is inadvertently redirected to the bladder
Some of these can be treated with medication or surgical procudures.
Medications
Prescription drugs, including anabolic steroids and Tagamet (which is used to treat stomach acid), can also affect the quality of sperm. Other medications can affect sperm motility, These include Azulfidine, to treat rheumatoid arthritis, and Macrobid, to treat bladder infections. Some other medications that can contribute to OAT include some antibiotics, antifungal drugs, medications to treat cancer, and ulcer drugs. Speak to your doctor about fertility-related side effects of any medications you are taking. There may be alternatives available.
A Word From Verywell
Many of the causes of male infertility can be treated. Even when they cannot be treated, there is an array of assisted reproductive procedures that can improve a couple’s chance of conceiving. They include fertility drugs, medical devices, surgery, or a combination of treatments. If you are experiencing male infertility, speak with a fertility specialist. Whatever the cause, they might be able to help.
