Look for active ingredients like permethrin or natural ingredients like mineral oil and tea tree oil, which can effectively treat head lice. Many lice shampoos are sold as full kits and include combs and helpful applicators as well. We carefully considered ingredients, application method, any age recommendations, and value when reviewing products. Here are the best lice shampoos to get rid of those pesky insects in a flash. The NIX Lice Killing Creme Rinse is our top pick because this brand is the biggest name in the lice-treating business, and permethrin, an FDA-approved ingredient for treating head lice. Permethrin, one of the active ingredients in this NIX shampoo, is a substance known to be extremely effective for killing lice and other mites (although for treatment-resistant super lice, you may need a prescription product). It’s safe for kids too, as long as your little one is over two months old. The kit comes with lice creme rinse and a comb to help comb out eggs and nits. Price at time of publication: $19 Similar to other lice treatments, the active ingredient in Mata Piojos is pyrethrum, which kills active bugs. To ensure complete elimination, you’ll have to apply a second treatment of Mata Piojos after seven to 10 days, since this formula doesn’t kill eggs.  Price at time of publication: $5 Although you’ll need a prescription from your child’s pediatrician to obtain Sklice, it’s super effective, with no nit combing required—lice are dead on contact when you use Sklice. It’s even approved for use in children as young as six months old. Price at time of publication: $22 If, however, you find yourself dealing with lice despite your best efforts to avoid them, Fairy Tales also offers a gentle and chemical-free lice treatment kit.  Price at time of publication: $22 If you’re tired of super smelly lice treatments that reek of chemicals or tea tree oil, you’ll be pleasantly surprised by HeadHunter’s Wipe Out. It’s got a light, fruity scent you’ll love.   Price at time of publication: $45 Users claim that this highly rated lice treatment is an effective alternative to more popular brands like NIX and RID. Though it may take a bit more time and diligence to completely eradicate head lice, reviewers say it’s worth it to avoid potentially harmful pesticides.  Price at time of publication: $30

Irritants

When they have lice, your kid’s scalp is already irritated. Be sure there’s nothing in the lice shampoo formula, like fragrance or alcohol, that could cause further irritation.

Combing or Comb-Free

Depending on your preference, you make want to have a comb-free lice shampoo to help reduce your time investment in getting rid of lice. If you don’t want to just kill lice, but also physically remove them, a shampoo that comes with a comb is the better way to go. The choice is up to you.